本发明涉及由至少一种稳定剂稳定的ACC颗粒，包含所述颗粒的药物组合物，以及使用所述颗粒的方法，例如用于治疗或预防有此需要的受试者中与酸中毒相关的疾病或病症。

A method for treating a subject afflicted with an acidosis-related disease or condition, comprising orally administering to said subject a therapeutically effective amount of a solid composition comprising amorphous calcium carbonate (ACC) particles stabilized by at least one stabilizing agent, wherein said solid composition of ACC particles is formulated for controlled release.