提供用于制备稳定的非晶形碳酸钙(ACC)的方法，所述稳定的非晶形碳酸钙可以以悬浮液或作为粉末得到。所述方法包括逐步合并如本文描述的可溶性钙盐、可溶性碳酸盐、第一稳定剂和第二稳定剂、以及水混溶性有机溶剂。本发明还涉及通过本发明的方法生产的稳定的ACC悬浮液和干燥粉末。

一种制备稳定的非晶形碳酸钙(ACC)悬浮液的方法，所述方法包括以下的步骤：i)将包含可溶性钙盐和第一稳定剂的水溶液与包含可溶性碳酸盐的水溶液合并，以便形成ACC悬浮液；以及ii)同时或以任何顺序依次添加水混溶性有机溶剂和包含第二稳定剂的溶液，只要所述第二稳定剂和所述水混溶性有机溶剂在形成所述ACC悬浮液的2分钟内接触所述ACC悬浮液，从而得到稳定的ACC悬浮液；其中所述第一稳定剂和所述第二稳定剂是相同或不同的；且其中稳定剂的总量构成所述稳定的ACC悬浮液的至多12重量％，且所述水混溶性有机溶剂构成所述稳定的ACC悬浮液的至少5重量％。

A method is provided for preparing stable amorphous calcium carbonate (ACC), which can be obtained in suspension or as a powder. The method comprises a step-by-step combination of a soluble calcium salt as described herein, a soluble carbonate, a first stabilizer and a second stabilizer, and a water-miscible organic solvent. The invention also relates to a stable ACC suspension and dry powder produced by the method of the invention.

A method for preparing a stable amorphous calcium carbonate (ACC) suspension comprises the following steps: i) combining an aqueous solution containing a soluble calcium salt and a first stabilizer with an aqueous solution containing a soluble carbonate in order to form an ACC suspension; And ii) a water-miscible organic solvent and a solution containing a second stabilizer are added simultaneously or sequentially in any order, provided that the second stabilizer and the water-miscible organic solvent come into contact with the ACC suspension within 2 minutes of the formation of the ACC suspension, resulting in a stable ACC suspension; The first stabilizer and the second stabilizer are the same or different; The total amount of the stabilizer constitutes up to 12% by weight of the stable ACC suspension, and the water-miscible organic solvent constitutes at least 5% by weight of the stable ACC suspension.